Common antidepressants are known to induce neurostructural and functional alteration in the mammalian brain and are released in urbanized river mouthpieces. As a consequence, they can potentially affect brain and behaviors of non-target marine species, including cuttlefish. NECC studies showed that antidepressants affect brain development: they modulate the levels of neurotransmitters in the brain and decrease cell proliferation in some brain areas. Antidepressants also change behavioral development (camouflage, feeding motivation) of juveniles when previously exposed to antidepressants during their first weeks of life. Studies of behavioral and neural effects of other anthropic disruptors are running, as underwater vibrations and turbidity. For this part of researches, a comparison is led between Sepia officinalis in the English Channel and Sepia pharaonis in the Red Sea.